Group-combinedP-values with applications to genetic association studies
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چکیده
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the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Power Calculation of Multi-step Combined Principal Components with Applications to Genetic Association Studies
Principal component analysis (PCA) is a useful tool to identify important linear combination of correlated variables in multivariate analysis and has been applied to detect association between genetic variants and human complex diseases of interest. How to choose adequate number of principal components (PCs) to represent the original system in an optimal way is a key issue for PCA. Note that th...
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Discovering important genes that account for the phenotype of interest has long been a challenge in genome-wide expression analysis. Analyses such as gene set enrichment analysis (GSEA) that incorporate pathway information have become widespread in hypothesis testing, but pathway-based approaches have been largely absent from regression methods due to the challenges of dealing with overlapping ...
متن کاملTopic Introduction Introduction to Genetic Association Studies
Genetic association studies test for a correlation between disease status and genetic variation to identify candidate genes or genome regions that contribute to a specific disease. A higher frequency of a singlenucleotide polymorphism (SNP) allele or genotype in a series of individuals affected with a disease can be interpreted as meaning that the tested variant increases the risk of a specific...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2016
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btw314